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Cetirizine hydrochloride tablets brand names Zyrtec, Imiglucerin and Eliquis) fluoxetine (Sinequan), which is the most widely prescribed antidepressant in the United States. FDA approved Tofranil (trade name Prozac) for the treatment of depression in 1984. The Food and Drug Administration (FDA) has set a deadline of 2015 for Tofranil—a delay several years over the original date of approval for the drug by federal agency in what is cetirizine hcl 10 mg tablet 1985. The delay is largely because drug's manufacturer, Eli Lilly, continues to face severe criticism over the high rate of adverse events. The most serious were reported in 2004, with the FDA approving drug to treat depression in only a handful of patients. The agency had previously approved Fluoxetine (Cymbalta) for depression in 2002, and Tofranil (Prozac) for depression in 2003. Tofranil was also approved for treating mild anxiety, obsessive-compulsive disorder, postpartum depression and bulimia nervosa, but did not initially receive the FDA's green light Order cialis online with mastercard to treat depression. The agency began investigating Tofranil for the treatment of depression in 2005, having long suspected it was a safe and effective antidepressant. There were two pivotal studies—in 1994 and 2001—conducted on Tofranil. When these studies were done, they concluded that Tofranil was safe and effective for the treatment of depression. Despite the positive findings, FDA was slow to give Tofranil the greenlight for treatment of depression. In April 2005, the drug was only approved for treatment of major depressive disorder, although some other conditions were also on the FDA's approved-for-use list. According to the FDA, a major reason agency was slow to approve Tofranil that the company, Lilly, did not submit the data in time. Lilly had initially submitted the data for drug in October 2001. According to the FDA, Lilly did not make it available in time after the agency asked company for data in 2004. At that point, Lilly had submitted a new package insert, in 2005, saying that it had made some changes to the drug and would soon be submitted to the FDA. But package insert also did not include the data. In response, FDA issued an alert concerning the delay in treatment. Lilly then submitted the data in January 2006. However, the package insert did not include any indication that the company had fixed problem what are cetirizine tablets taken for with the drug. FDA then sent Lilly three letters asking it to submit the data in a timely fashion. The company then submitted data in February 2006 and the FDA issued an alert in February 2006 saying that the new package insert would require that Tofranil be resubmitted. Lilly then submitted the data in February 2006 and the FDA issued an alert in August 2007. The FDA had approved drug to treat depression in 2004, but the package insert said that drug was not approved for the treatment of major depressive disorder. Lilly did not resubmit the data to FDA until March 2008. The FDA then delayed approval of Tofranil for treatment depression until 2015, as the new package insert included recommendations about how the drug should be used. recommendations suggested that people with major depressive disorder might be able to receive Tofranil by switching the generic version of drug and not taking the full-strength version. The drug, which was first approved in 1984 for depression, is now among the most prescribed antidepressants in United States. 2011, the percentage of prescriptions for antidepressants and other prescription-drug uses of antidepressants among children and adolescents in the United States totaled 4.2 percent, according to data from the Centers for Disease Control and Prevention (CDC). In 2012, the most Best drugstore bronzer australia recent year for which data on the overall use of antidepressants are available, what are cetirizine dihydrochloride tablets for the prescribing rate for antidepressants—including Tofranil—among children and adolescents aged 12 to 17 years was 9.1 percent. According to the FDA, Tofranil has been licensed to treat depression in more than 35 countries around the world.

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